The Environmental Protection Agency (EPA) is preparing an Integrated Science Assessment (ISA) as part of the review of the primary and secondary National Ambient Air Quality Standards (NAAQS) for Lead (Pb). The ISA will be completed by EPA’s Office of Research and Development’s Center for Public Health and Environmental Assessment (CPHEA). When final, the ISA is intended to update the previous Pb ISA (EPA/600/R-10/075F), published on June 26, 2013. Interested parties are invited to assist EPA in developing and refining the scientific information base for the review of the Pb NAAQS by submitting research studies and data that have been published, accepted for publication, or presented at a public scientific meeting since January 1, 2011.