On September 23, 2025, the U.S. Environmental Protection Agency (EPA) proposed highly anticipated amendments to the procedural framework rule for conducting existing chemical risk evaluations under the Toxic Substances Control Act (TSCA). 90 Fed. Reg. 45690. Comments on the proposed rule are due November 7, 2025. EPA states that under the Paperwork Reduction Act, “comments on the information collection provisions are best assured of consideration if the Office of Management and Budget (OMB) receives a copy of your comments on or before October 23, 2025.” The proposed rule is well crafted and the changes to the risk evaluation framework are unsurprising. For more information on the amendments and our commentary, please read the full memorandum.

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