On December 2, 2021, the U.S. Environmental Protection Agency (EPA) published an updated New Approach Methods (NAM) Work Plan (Updated Work Plan). EPA created the work plan to prioritize its efforts and resources toward activities that aim to reduce the use of vertebrate animal testing while continuing to protect human health and the environment. EPA describes its updated roadmap and identifies steps intended to reduce the use of vertebrate animals for toxicity testing and related research while ensuring that its regulatory, compliance, and enforcement activities remain protective of human health and the environment. In the Updated Work Plan, EPA discusses the near- and long-term strategies it will deploy through 2024 to accomplish its objectives, working across offices and with stakeholders, and the different deliverables on which it will focus. For more information, please read the full memorandum.